June 4, 2018 The PD-1/PD-L1 pathway is commonly upregulated in Merkel cell carcinoma (MCC), a rare aggressive form of skin cancer often associated with the Merkel cell polyomavirus (MCPyV). The multicenter, phase I/II CheckMate-358 trial (NCT02488759) was designed to determine the safety and tolerability of neoadjuvant nivolumab in patients with advanced, virus-associated cancers. Immunologic changes...
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